Interleukin-6 family of cytokines and gp130
نویسندگان
چکیده
منابع مشابه
Interleukin-6 family of cytokines and gp130.
G ROWTH AND DIFFERENTIATION of cells in the immune and hematopoietic systems are regulated by cytokines or interleukins. One of the characteristic features of cytokines is their functional pleiotropy and redundancy, ie, one cytokine shows a wide variety of biologic functions on various tissues and cells, and several different cytokines exert similar and overlapping functions on a certain cell. ...
متن کاملAssociation and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines.
Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotrophic factor constitute the IL-6 family of cytokines and play important roles in hematopoiesis, immune response, and nervous system. The receptors for the IL-6 family of cytokines share gp130 through which signals are generated, although the cytoplasmic region of gp130 does not contain any catalytic domain...
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Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. It is believed to be caused by exposure to pathogenic antigens in genetically susceptible individuals but the causative antigen has not been identified. The formation of non-caseating granulomas at sites of ongoing inflammation is the key feature of the disease. Other aspects of the pathogenesis are peripheral T-...
متن کاملExpression of the interleukin-6 (IL-6), IL-6 receptor, and gp130 genes in acute leukemia.
Expression patterns of interleukin-6 (IL-6), IL-6 receptor (IL-6R), and gp130 genes in 39 patients with acute myeloid leukemia (AML), in 23 patients with acute lymphoblastic leukemia (ALL), and in 7 patients with acute mixed lineage leukemia (AMLL) were studied by quantitative reverse transcriptase-polymerase chain reaction. Significant levels of IL-6 were expressed in 8 (21%) of 39 AML patient...
متن کاملDimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb.
The objective of our research was to study the mechanisms of activation of mAb against the gp130 transducer chain common to the IL-6 cytokine family. It has been found that among the 56 anti-gp130 available worldwide, none was able to activate the growth of IL-6-dependent myeloma cell lines. When certain of them were associated in pairs they allowed the cells to grow; alone, they were inhibitor...
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ژورنال
عنوان ژورنال: Blood
سال: 1995
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v86.4.1243.bloodjournal8641243